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Objective. To determine a possible assessment of the verification of the genetic group of medulloblastomas based on MRI imaging and quantitative assessment indicators. Materials and Methods . MRI data of 60 patients with a verified molecular genetic subgroup based on the expression level of selected genes on the Nano String platform were retrospectivel analyzed. Results. Based on MRI signs of the shape and contrast intensity of the tumor, taking into account the age of the patients, 76 % of medulloblastomas were correctly identified by genetic groups. Conclusion . The ability to predict the genetic group of the disease in children with medulloblastoma during an initial MRI study with an accuracy of 76 % seems to us important and relevant. Only the first steps have been taken in the development of radiogenomics of medulloblastomas in children. The classification of CNS tumors with the molecular subgroups of medulloblastomas has allowed modern pediatric oncological practice to apply a differentiated approach to stratification of risk groups and prognosis of the disease. This affects the determination of the scope and the tactics of treatment. The aim of our study was an attempt to systematize and definition the diagnostic radiological signs of the currently known four molecular subgroups of medulloblastomas in children. Thirty-nine (76%) patients diagnosed with medulloblastoma were correctly classified into genetic groups based on radiographic features of shape, contrast intensity, and patient age.
Терещенко et al. (Mon,) studied this question.