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Abstract Objectives To evaluate periodontal wound healing following scaling and root planing (SRP) in conjunction with the application of sodium hypochlorite/amino acids and cross-linked hyaluronic acid (xHyA) gels in dogs. Materials and Methods In four beagle dogs, 2-wall intrabony defects were created and metal strips were placed around the teeth. Clinical parameters were measured 4 weeks after plaque accumulation. The experimental root surfaces were subjected to SRP with either the subgingival application of a sodium hypochlorite/amino acid gel and a xHyA gel (test group) or SRP alone (control group) using a split-mouth design. Clinical parameters were re-evaluated at 6 weeks. The animals were sacrificed at 8 weeks for histological analysis. Results The test group showed significant improvements in all clinical parameters compared to the control group. Histologically, the test group exhibited statistically significantly greater new bone formation i.e., length of newly formed bone, new bone area compared with the control group ( p < 0.05). Furthermore, statistically significantly greater formation of new attachment i.e., linear length of new cementum adjacently to newly formed bone with inserting collagen fibers and new cementum was detected in the test group compared with the control group at 8 weeks ( p < 0.05 and p < 0.01, respectively). Conclusion The adjunctive subgingival application of sodium hypochlorite/amino acid and xHyA gels to SRP offers an innovative novel approach to enhance periodontal wound healing/regeneration. Clinical relevance The present findings have for the first-time shown histologic evidence for periodontal regeneration in support of this novel treatment modality.
Shirakata et al. (Sat,) studied this question.