Key points are not available for this paper at this time.
Diclofenac is an analgesic and belongs to the non steroidal and anti inflammatory drug NSAIDS that is widely used to tricot pain and inflammation. When used by the oral route, only about 50% of absorbed dose of diclofenac becomes systematically available due to first-pass metabolism. The objectives of the present investigation were the product quality and performance must be comparable to the innovator product in the order to ensure therapeutical equivalence. The present study is to formulate nanosize dispersion of diclofenac sodium by emulsion solvent diffusion method and incorporation of gelling agent to product nanogel. The formulation and characterized for particle size range from 100-400 nanometers. A drug name diclofenac sodium used in chronic diseases. FTIR spectrum it was concluded that the drug sample was in pure form. It was found that drug absorbance is 226 & 276 nm but maximum absorbance was at 276nm. When solution is prepared in distilled water for quantitative evaluation purpose through the medium of evaluation of release in phosphate buffer PH 6.8. The graph absorbance Vs concentration was found to be linear in the concentration range of 424µg/ml at 276nm. The R2 of the calibration curve was found to be 0.999. Nanogel formation containing diclofenac sodium was successfully prepared and shows effective as was as better carrier for the topical preparation. The production of formulation also proceeds be better and cost effective comparision with oral dosage forms.
Lakshmisavithri et al. (Tue,) studied this question.