Mp63-10 Association Between Dietary Antioxidant Intakes and Kidney Stone Prevalence in Adults: A Cross-Sectional Analysis of Nhanes 2007-2018

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology (MP63)1 May 2024MP63-10 ASSOCIATION BETWEEN DIETARY ANTIOXIDANT INTAKES AND KIDNEY STONE PREVALENCE IN ADULTS: A CROSS-SECTIONAL ANALYSIS OF NHANES 2007-2018 Qixin Duan, Shuang Zhang, Dongming Lu, Yingming Sun, and Yongyang Wu Qixin DuanQixin Duan , Shuang ZhangShuang Zhang , Dongming LuDongming Lu , Yingming SunYingming Sun , and Yongyang WuYongyang Wu View All Author Informationhttps://doi.org/10.1097/01.JU.0001009436.52988.91.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Kidney stones, a prevalent ailment affecting adults globally, have prompted research into potential preventive measures. One avenue explored is the consumption of antioxidants, which may offer protection against kidney stone development. This study's objective was to investigate the correlation between the Composite Dietary Antioxidant Index (CDAI) and the prevalence of kidney stones. METHODS: The study employed a cross-sectional design and utilized data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). This study enrolled participants aged over 20 years with complete data on the intake of six dietary antioxidants (including vitamins A, vitamins C, vitamins E, zinc, selenium, and carotenoid) and kidney stone prevalence. Subsequently, the composite dietary antioxidant index (CDAI) was calculated by summing the standardized dietary antioxidant intakes and multivariate logistic regression and restricted cubic spline (RCS) regression were performed between CDAI and kidney stone prevalence. RESULTS: A total of 28,516 participants were included in the study, among whom 2,748 self-reported having kidney stones. The mean CDAI (SE) was 0.55 (0.05) and participants in the fourth quartile of CDAI scores had a 23% lower prevalence of kidney stones compared to those in the first quartile (OR=0.77 95%CI: 0.63-0.94, p for trend <0.01). RCS regression indicated a non-linear and negative relationship between CDAI and kidney stone prevalence (p for non-linearity = 0.04). Furthermore, analysis of individual CDAI components revealed that Vitamins C, Zinc, and Selenium showed a linear and negative correlation with kidney stone prevalence, while Vitamins A, Vitamins E, and Carotenoid did not show any significant association. Stratified analysis did not identify variables that significantly influenced the results, and sensitivity analyses confirmed the robustness of the findings. CONCLUSIONS: This study provides evidence that higher dietary antioxidant intakes, particularly Vitamins C, Zinc, and Selenium, are associated with a reduced prevalence of kidney stones in adults. The non-linear relationship between CDAI and kidney stone prevalence suggests that a balanced intake of dietary antioxidants may be beneficial in preventing kidney stone formation. Download PPT Source of Funding: Natural Science Foundation of Fujian Province, China (No.2019J01588) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1034 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Qixin Duan More articles by this author Shuang Zhang More articles by this author Dongming Lu More articles by this author Yingming Sun More articles by this author Yongyang Wu More articles by this author Expand All Advertisement PDF downloadLoading ...