MP22-03 THE EFFECT OF LYMPHOVASCULAR INVASION ON ONCOLOGICAL OUTCOMES BETWEEN pT2 AND ypT2 IN PATIENTS WITH MUSCLE-INVASIVE UROTHELIAL CARCINOMA

You have accessJournal of UrologyBladder Cancer: Invasive II (MP22)1 May 2024MP22-03 THE EFFECT OF LYMPHOVASCULAR INVASION ON ONCOLOGICAL OUTCOMES BETWEEN pT2 AND ypT2 IN PATIENTS WITH MUSCLE-INVASIVE UROTHELIAL CARCINOMA Hirotaka Horiguchi, Shingo Hatakeyama, Ryuji Tabata, Toshikazu Tanaka, Teppei Okamoto, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Satoshi Sato, and Chikara Ohyama Hirotaka HoriguchiHirotaka Horiguchi , Shingo HatakeyamaShingo Hatakeyama , Ryuji TabataRyuji Tabata , Toshikazu TanakaToshikazu Tanaka , Teppei OkamotoTeppei Okamoto , Hayato YamamotoHayato Yamamoto , Takahiro YoneyamaTakahiro Yoneyama , Yasuhiro HashimotoYasuhiro Hashimoto , Satoshi SatoSatoshi Sato , and Chikara OhyamaChikara Ohyama View All Author Informationhttps://doi.org/10.1097/01.JU.0001008608.50694.4b.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We aimed to investigate the impact of lymphovascular invasion (LVI) on oncological outcomes between pT2 and ypT2 in patients with muscle-invasive urothelial carcinoma (MIUC). METHODS: We retrospectively evaluated 1406 patients with MIUC who were treated with radical cystectomy (n=771) or radical nephroureterectomy (n=620). We selected patients with pT2 or ypT2 and compared disease-free survival (DFS) and overall survival (OS) between the groups. The effect of LVI status on outcomes were evaluated by multivariable Cox regression analysis. RESULTS: Of 1406, we identified 169 and 154 patients with pT2 and ypT2, respectively. DFS and OS were significantly shorter in the ypT2 group than those in the pT2 group. A poor DFS and OS was observed in the patients with pT2/ypT2 and LVI+compared with LVI-. We observed similar median DFS (95.3 vs. 96.6 mo.) and OS (96.7 vs. 96.4 mo.) between the LVI+in pT2 and LVI- in ypT2. Multivariable Cox regression analysis showed LVI+was significantly associated with poor DFS and OS. Nomogram for 5-year DFS showed LVI+was associated with 14% reduction of survival probability. CONCLUSIONS: The impact of LVI on oncological outcomes was significant in both pT2 and ypT2 MIUC. Download PPTDownload PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e341 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Hirotaka Horiguchi More articles by this author Shingo Hatakeyama More articles by this author Ryuji Tabata More articles by this author Toshikazu Tanaka More articles by this author Teppei Okamoto More articles by this author Hayato Yamamoto More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Satoshi Sato More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement PDF downloadLoading ...