Review of synthesis process of benzoxazole and benzothiazole derivatives

Benzoxazoles and benzothiazoles are a class of aromatic heterocyclic compounds having similar ring structures, in which a benzene ring is fused to the 4 and 5 positions of the 1,3-oxazole and 1,3-thiazole rings respectively. They constitute an interesting class of organic compounds due to their powerful and significant biological, agrochemical, pharmaceutical and physicochemical activities. Indeed, benzoxazole and benzothiazole derivatives possess a wide range of applications, such as: anticancer, anti-inflammatory, antioxidant, anticonvulsant, antitubercular, antifungal, pesticidal, anticorrosive, complexing properties and so on. The synthesis of benzoxazole and benzothiazole derivatives has attracted much attention from several researchers across the world and numerous synthetic methods have been developed to access these compounds over the past decades. In this review, we present new and recent synthetic strategies, as well as some biological properties of benzoxazole and benzothiazole derivatives.