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Abstract Background: Leaf extract of Jati ( Jasminum grandiflorum L.) has been proven to possess dermal wound healing and anti-ulcer activities. Mukhapaka (aphthous stomatitis) is the most common lesion of the oral cavity. For its management, Jati mouthwash was formulated by the Arka (distillation), and its efficacy was compared with the traditional form of Jati Kwatha (decoction). Due consideration was given to patient compliance, convenience of usage, increased shelf-life, no preservative, easy storage, and dispensing. Aims: The aim of this study was to evaluate the efficacy of Jati mouthwash and Jati Kwatha Kavala (gargle) in the management of Mukhapaka . ] Materials and methods: Forty-five patients having the classical symptoms of Mukhapaka were randomized into three groups as Jati mouthwash (group 1), Jati Kwatha Kavala (group II ) , and placebo (group III), all preparations were administered twice daily for seven days. The assessment was done by scoring method evaluating the oral ulcer activity, ulcer-related pain and functional disability, and Visual Analog Scale (VAS) at the baseline each day. Statistical evaluation was done within groups using paired t -test and between the groups using ANOVA post hoc multiple comparisons – Tukeys test. Results: Significant reductions was observed in VAS score for pain and other symptoms in the Jati mouthwash group at the end of seven days. Furthermore, the mouthwash group noted an accelerated mean healing period. Gas chromatography–mass spectrometry spectrum of the drug in its modified form as distillate revealed the presence of thymol and carvacrol, which are proven effective against oral pathogens but were absent in the Kwatha . Conclusion: Although the disease is self-limiting and the management is supportive, the Jati mouthwash was found to be better than its classical form of Kwatha or decoction.
Balakrishnan et al. (Mon,) studied this question.
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