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IGF-1 plays a pivotal role in promoting cell proliferation and growth, making it a key factor in growth-related diseases such as osteoporosis and diabetes. Serum IGF-1 levels can contribute to abnormal growth patterns, underscoring its significance in the pathophysiology of these conditions. Gender-based IGF-1 analysis is crucial for understanding and addressing variations in insulin-like growth factor-1 levels between men and women, providing valuable insights into potential gender-specific health implications and optimizing personalized healthcare interventions. The present study focuses gender based analysis in south Indian population because race is also one of the important factor in IGF 1 level. In this study, 195 blood samples have been collected from male and female volunteers and their IGF 1 value were quantified using systematic biochemical procedure with the help of ELIZA reader. Age-related analysis showed that IGF levels decrease with older age in both men and women. Women have significantly lower IGF 1 levels than men (p. Especially during menopause, the IGF-1 levels of women decrease significantly. The bone mineral density T-score is low and showed greater correlation with IGF-1 level in female than male, which may be the reason for the high incidence of osteoporosis in women. However, further studies with different severities of osteoporosis are needed.
Sridevi et al. (Thu,) studied this question.