The Impact of Human Genome on Interindividual variability in Drug Response

Pharmacogenomics is an important aspects of clinical genomics i.e an increasingly large number of patients it have extremely broad cast application a pharmacogenomics has evolved from early Pharmacogenetic studies of candidate gene often genes. Pharmacogenomics has the potential to mitigate adverse drug reaction and optimise pharmaco therapy in individual it has the potential to revolutionize the practice of medicine and promises to in an area of personised medicine in which drug and drug combination optimised for each Individual unique genetic makeup. It is well recognised that most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications interindividual differences in polymorphism of incoding genes in drug metabolising enzymes drug transporter, Target drugs eg. receptors, enzymes. The ultimate goal is to provide new strategies for optimising drug therapy based on each patient genetic determinants of drug efficacy and toxicity.