Amide proton transfer weighted imaging in pediatric neuro‐oncology: initial experience

Abstract Amide proton transfer weighted (APTw) imaging enables in vivo assessment of tissue‐bound mobile proteins and peptides through the detection of chemical exchange saturation transfer. Promising applications of APTw imaging have been shown in adult brain tumors. As pediatric brain tumors differ from their adult counterparts, we investigate the radiological appearance of pediatric brain tumors on APTw imaging. APTw imaging was conducted at 3 T. APTw maps were calculated using magnetization transfer ratio asymmetry at 3.5 ppm. First, the repeatability of APTw imaging was assessed in a phantom and in five healthy volunteers by calculating the within‐subject coefficient of variation (wCV). APTw images of pediatric brain tumor patients were analyzed retrospectively. APTw levels were compared between solid tumor tissue and normal‐appearing white matter (NAWM) and between pediatric high‐grade glioma (pHGG) and pediatric low‐grade glioma (pLGG) using t ‐tests. APTw maps were repeatable in supratentorial and infratentorial brain regions (wCV ranged from 11% to 39%), except those from the pontine region (wCV between 39% and 50%). APTw images of 23 children with brain tumor were analyzed (mean age 12 years ± 5, 12 male). Significantly higher APTw values are present in tumor compared with NAWM for both pHGG and pLGG ( p < 0.05). APTw values were higher in pLGG subtype pilocytic astrocytoma compared with other pLGG subtypes ( p < 0.05). Non‐invasive characterization of pediatric brain tumor biology with APTw imaging could aid the radiologist in clinical decision‐making.