February 15, 2024Open Access

Diesel exhaust particle exposure exacerbates ciliary and epithelial barrier dysfunction in the multiciliated bronchial epithelium models

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Abstract

Airway epithelium, the first defense barrier of the respiratory system, facilitates mucociliary clearance against inflammatory stimuli, such as pathogens and particulates inhaled into the airway and lung. Inhaled particulate matter 2.5 (PM

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Park et al. (Thu,) studied this question.

synapsesocial.com/papers/68e78f66b6db6435877011dc https://doi.org/https://doi.org/10.1016/j.ecoenv.2024.116090

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1Mucus clearance as a primary innate defense mechanism for mammalian airways2002 · 1,018 citations
2Comparative toxicity of ultrafine particles around a major airport in human bronchial epithelial (Calu-3) cell model at the air–liquid interface2020 · 41 citations
3Ciliary defects and genetics of primary ciliary dyskinesia2009 · 86 citations
4The cellular impacts of diesel exhaust particles: beyond inflammation and death2006 · 41 citations
5Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism2007 · 96 citations

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