Given a family of varieties, the Euler discriminant locus distinguishes points where Euler characteristic differs from its generic value. We introduce a hypergeometric system associated with a flat family of very affine locally complete intersection varieties. It is proven that the Euler discriminant locus is its singular locus and is purely one-codimensional unless it is empty. Of particular interest is a family of very affine hypersurfaces. We coin the term hypergeometric discriminant for the characteristic cycle of the hypergeometric system and establish a formula in terms of likelihood equations.
Saiei-Jaeyeong Matsubara-Heo (Mon,) studied this question.