Abstract Objective: The study assessed the efficacy of different implant surface decontamination methods in surgical peri-implantitis (PI) treatment, considering the immune response. Material and Methods: Forty-four patients (aged 58.7 ± 9.4) dignosed with 52 peri-implantitis (peri-implant probing depth, (PPD) > 5 mm, bleeding on probing (BOP “+”), and bone loss > 2 mm) completed a two-year study. ISD was employed by either photodynamic therapy (PDT, test group) or 1% chlorhexidine di-gluconate gel (control group) followed by peri-implant bone defects reconstruction. Interleukins (IL) 17A, IL-1β, and IL-6 concentrations, clinical and radiographic outcomes were assessed throughout 24 months postoperatively. Results: IL-17A, IL-1β, and IL-6 concentrations were significantly reduced 24 months postoperatievly (p = 0.007, p Conclusion: PDT may provide a feasible method for implant surface decontamination, improving immune response in reconstructive peri-implantitis treatment. Clinical relevance:A reconstructive peri-implantitis surgery combined with PDT effectively decreases pro-inflammatory interleukin during the first 24 months postoperatively, significantly enhancing clinical and radiographic outcomes. Study was registered retrospectively at ClinicalTrials.com (NCT05187663).
Rakašević et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: