Design, synthesis, and multi-target anticancer evaluation of 1,3-thiazolodin-4-one analogues against breast cancer: mechanistic insights into estrogen metabolism, inflammation, angiogenesis, and oxidative stress

Key Points

• To design and evaluate the anticancer effects of 1,3-thiazolodin-4-one analogues against breast cancer.
• Synthesis of 1,3-thiazolodin-4-one analogues
• Multi-target evaluation against breast cancer
• Assessment of estrogen metabolism, inflammation, angiogenesis, and oxidative stress mechanisms
• 1,3-thiazolodin-4-one analogues showed significant antitumor activity against breast cancer cells
• Mechanistic insights included modulation of inflammation and oxidative stress
• Potential pathways affected include estrogen metabolism and angiogenesis