What question did this study set out to answer?

To develop a self-adjuvating hydrogel that supports the codelivery of antigens and adjuvants for an immune response.

January 14, 2026Nanoscale0 citationsOpen Access

Mn²⁺-Coordinated Glycyrrhizic Acid Self-Adjuvating Hydrogel for Sustained Codelivery of Antigen and Mn²⁺ for a Potent Immune Response

JZjingjing ZhouLanzhou Veterinary Research Institute SZShengying ZhangLanzhou Veterinary Research Institute HDHu DongLanzhou Veterinary Research Institute

Key Points

To develop a self-adjuvating hydrogel that supports the codelivery of antigens and adjuvants for an immune response.
Constructed a self-adjuvating hydrogel using Mn²⁺ and Glycyrrhizic Acid through self-assembly.
Evaluated sustained codelivery of antigens and Mn²⁺.
Investigated immune response elicited by the hydrogel.
The hydrogel induced a significantly enhanced immune response.
Sustained codelivery of antigens and Mn²⁺ was observed.

Abstract

The development of vaccine platforms that enable sustained codelivery of antigens and adjuvants remains a major challenge in modern vaccinology. Herein, we constructed a self-adjuvating hydrogel (GA@Mn) via the self-assembly...

Demander à l'IA

Bookmark

View Full Paper

Cite This Study

Zhou et al. (Thu,) studied this question.

synapsesocial.com/papers/6966f2fb13bf7a6f02c0078f https://doi.org/https://doi.org/10.1039/d5nr04283f

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Demander à l'IA

Bookmark

View Full Paper