What question did this study set out to answer?

This research investigates whether body mass index (BMI) independently predicts outcomes after TAVR in a Saudi population.

January 18, 2026Life0 citationsOpen Access

Impact of Body Mass Index on In-Hospital Outcomes After Transcatheter Aortic Valve Replacement: A Retrospective Cohort Study from Saudi Arabia

FKFawaz KhatebUmm al-Qura University YTYosra TurkistaniUmm al-Qura University ARAbdullah RawasUmm al-Qura University

Key Result

BMI was not independently associated with in-hospital complications after TAVR, but overweight patients had higher infection rates (14.1% vs. ~3%, p = 0.020).

Key Points

This research investigates whether body mass index (BMI) independently predicts outcomes after TAVR in a Saudi population.
Conducted a retrospective analysis of 197 patients undergoing TAVR from 2015 to 2024
Stratified patients by BMI categories: <25, 25-29.9, and ≥30 kg/m²
Analyzed in-hospital complications, mortality rates, and other outcomes using VARC-3 criteria
In-hospital mortality was 2.0% with a technical success rate of 99%
Overweight patients had higher infection rates of 14.1% compared to ~3% for others
Age ≥ 75 years and moderate to high STS risk independently predicted complications

Structured PICO

Does BMI independently predict early complications, mortality, or infection following TAVR in a Saudi Arabian cohort?

Population

197 patients in a Saudi Arabian cohort who underwent transcatheter aortic valve replacement (TAVR) between 2015 and 2024, mean age 74.9 ± 8.8 years, 52.3% female.

Intervention

Body mass index (BMI) categories (BMI < 25, 25–29.9, and ≥30 kg/m2) as an exposure variable during TAVR.

Comparator

Comparison across the three BMI categories (< 25, 25–29.9, and ≥30 kg/m2).

Outcome

In-hospital Valve Academic Research Consortium-3 (VARC-3) composite safety outcome.composite

Physiologic vulnerability and operative risk (such as advanced age and STS risk score), rather than BMI alone, should guide early TAVR risk assessment.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Body mass index (BMI) has shown inconsistent associations with outcomes after transcatheter aortic valve replacement (TAVR), and evidence from the Middle Eastern population is limited. This study evaluated whether BMI independently predicts early complications, mortality, or infection following TAVR in a Saudi Arabian cohort. We conducted a retrospective analysis of 197 patients who underwent TAVR between 2015 and 2024, stratified by BMI < 25, 25–29.9, and ≥30 kg/m2. The primary endpoint was the in-hospital Valve Academic Research Consortium-3 (VARC-3) composite safety outcome, with secondary outcomes including individual complications, infection, length of stay, and 30-day mortality or readmission. Overall, patients had a mean age of 74.9 ± 8.8 years and 52.3% were female; in-hospital mortality was 2.0%, technical success 99%, and 30-day readmission 12.7%. BMI category was not independently associated with in-hospital complications or mortality, while advanced age ≥ 75 years (adjusted OR 2.52, p = 0.009), moderate Society of Thoracic Surgeons (STS) risk (adjusted OR 3.75, p = 0.008), and high STS risk (adjusted OR 2.26, p = 0.033) independently predicted complications. Overweight patients had higher in-hospital infection rates (14.1% vs. ~3%, p = 0.020). These findings suggest that physiologic vulnerability and operative risk, rather than BMI alone, should guide early TAVR risk assessment.

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