Abstract Background: Segmental bone defects resulting from trauma, infection, or tumour resection are difficult to manage and often lead to prolonged disability. The Masquelet Induced Membrane Technique (IMT) is a two-stage reconstructive procedure that has shown promising biological and clinical outcomes. Objective: To assess the clinical, biochemical, radiological, and functional outcomes of patients with segmental long-bone defects treated using the Masquelet technique. Materials and Methods: Thirty-three patients with segmental bone defects were treated prospectively using IMT between 2022 and 2024. Data collected included demographic details, biochemical parameters (ESR, CRP), cortical union, bone and functional scores, and patient-reported outcomes using PCS-12, MCS-12, and VAS. Results: The mean patient age was 34.3 ± 6.1 years, with a male predominance (54.5%). The tibia was the most frequently involved bone (42.4%). ESR and CRP showed significant reduction before second-stage surgery (p < 0.001). By 6 months, 94% achieved ≥ grade 3 cortical union, and 88.4% demonstrated excellent functional recovery. PCS-12, MCS-12, and VAS scores improved markedly, confirming both objective and subjective recovery. Conclusion: The Masquelet Induced Membrane Technique is a reliable, reproducible, and biologically sound method for reconstructing large bone defects. It achieves excellent radiological consolidation, pain relief, and functional restoration with minimal complications when performed with meticulous technique and strict infection control.
International Journal of Medical Science and Advanced Clinical Research (IJMACR) (Sun,) studied this question.