A one SD higher MetaboHealth score was associated with 9.02 seconds slower performance on the Stroop test (95% CI 7.29-10.75) and 2.79 less digits coded on the LDCT (95% CI 2.21-3.26).
Cohort (n=5,292)
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null
Yes
Does a higher MetaboHealth score associate with worse cognitive function and functional decline in older adults at increased cardiovascular risk?
An increased 1H-NMR metabolomics-based health score is associated with worse cognitive performance and faster functional decline in older adults at high cardiovascular risk.
Effect estimate: null (95% CI 7.29-10.75)
p-value: p=<0.001
Abstract The 1-HMR metabolomics-based MetaboHealth score, comprised of 14 serum metabolic markers, associates with disease-specific mortality, but it is unclear whether the score also reflects cognitive changes and functional impairment. We aimed to assess the associations between the MetaboHealth score with cognitive function and functional decline in older adults at increased cardiovascular risk. A total of 5292 older adults free of dementia at baseline with mean age 75.3 years (SD = 3.4) from the Prospective Study of Pravastatin in the Elderly (PROSPER). MetaboHealth score were measured at baseline, and cognitive function and functional independence were measured at baseline and every 3 months during up to 2.5 years follow-up. Cognitive function was assessed using the Stroop test (selective attention), the Letter Digit Coding test (LDCT) (processing speed), and the two versions of the Picture Learning test (delayed and immediate; memory). Two tests of functional independence were used: Barthel Index (BI) and instrumental activities at daily living (IADL). A higher MetaboHealth score was associated with worse cognitive function (in all domains) and with worse functional independence. For example, after full adjustments, a 1-SD higher MetaboHealth score was associated with 9.02 s (95%CI 7.29, 10.75) slower performance on the Stroop test and 2.79 (2.21, 3.26) less digits coded on the LDCT. During follow-up, 1-SD higher MetaboHealth score was associated with an additional decline of 0.53 s (0.23, 0.83) on the Stroop test and − 0.08 (− 0.11, − 0.06) points on the IADL. Metabolic disturbance, as reflected by an increased metabolomics-based health score, may mark future cognitive and functional decline.
Zonneveld et al. (Tue,) conducted a cohort in cognitive impairment and functional independence in older adults at risk of cardiovascular disease (n=5,292). MetaboHealth score vs. null was evaluated on Cognitive and functional decline (null, 95% CI 7.29-10.75, p=<0.001). A one SD higher MetaboHealth score was associated with 9.02 seconds slower performance on the Stroop test (95% CI 7.29-10.75) and 2.79 less digits coded on the LDCT (95% CI 2.21-3.26).