Iridium-catalyzed intramolecular allylic substitution reaction: efficiently enantioselective synthesis of 1,3,4-oxadiazine, oxazo-lines and 1,3-oxazine derivatives

Key Points

• This research aims to develop an efficient method for synthesizing N,O-heterocycles using iridium catalysis.
• Used iridium as a catalyst for the reaction.
• Focused on intramolecular allylic substitution.
• Targeted the synthesis of five- and six-membered N,O-heterocycles.
• Successfully achieved high enantioselectivity in the synthesis.
• Developed a straightforward approach to diverse heterocycle derivatives.
• Demonstrated practicality and efficiency of the reaction method.