Patients undergoing transcatheter tricuspid valve repair showed significant improvements in malnutrition scores, TR volume, and quality of life, with 74% demonstrating nutritional improvement post-pro
Does transcatheter tricuspid valve edge-to-edge repair (TTVR) improve nutritional status in patients with moderate-to-severe tricuspid regurgitation?
Nutritional impairment is highly prevalent in severe tricuspid regurgitation, and successful transcatheter repair is associated with improved nutritional status, which correlates with better right heart and hepatorenal function.
Absolute Event Rate: 0% vs 0%
Abstract Aims To characterize the prevalence and clinical relevance of malnutrition in patients undergoing transcatheter tricuspid valve edge-to-edge repair (TTVR). Methods and results Overall, 86 consecutive patients (mean age 78 ± 7 years) with moderate-to-severe tricuspid regurgitation (TR) at prohibitive surgical risk were analysed. Mini Nutritional Assessment (MNA), quality of life assessment, 6-min walk test distance and laboratory analyses were performed before and 1 month after TTVR. A total of 43 patients (50%) underwent concomitant transcatheter mitral valve repair. According to MNA, 81 patients (94%) were malnourished or at risk of malnutrition before TTVR. Following TTVR, MNA improved in 64 patients (74%). As compared to patients without MNA improvement, patients with increased MNA score had greater reductions in TR regurgitation volume −17.0 (interquartile range, IQR −25.0; −7.0) mL vs. −26.4 (IQR −40.3; −14.5) mL, P 0.001 and inferior vena cava diameter. Only patients with increased MNA score displayed a decrease in N-terminal pro-brain natriuretic peptide levels −320 (IQR −1294; 105) pg/mL vs. +708 (IQR −342; 2708) pg/mL, P = 0.009, improvements in cholinesterase levels (0.0 ± 11.9 μmoL/L vs. +10.9 ± 16.7 μmoL/L, P 0.001) and renal function during follow-up. Beneficial effects on quality of life scores and 6-min walk test distance following TTVR were observed exclusively in patients with improvement in MNA. During a median follow-up of 6 months, patients with worsened MNA had an increased risk of death and rehospitalization for heart failure. Conclusion Nutritional impairment is common and of prognostic importance in patients undergoing TTVR. Hepatorenal function modestly improves after successful TTVR. Further study of extracardiac implications of TR-associated right heart failure is warranted to improve care in this vulnerable patient population.
Besler et al. (Wed,) reported a other. Patients undergoing transcatheter tricuspid valve repair showed significant improvements in malnutrition scores, TR volume, and quality of life, with 74% demonstrating nutritional improvement post-pro.