Design and Synthesis of 2,4-disubstituted Thiazole Amide Derivatives as Potential Anti-schizophrenia Agents

Key Points

• The study aims to explore the design and potential of thiazole amide derivatives as anti-schizophrenia agents targeting GPR52.
• Design and synthesize 2,4-disubstituted thiazole amide derivatives
• Evaluate binding affinity to GPR52
• Assess interaction with D1 and D2 dopamine receptors
• New thiazole amide derivatives show significant activity against GPR52
• Compounds indicate selective binding to dopamine receptors relevant to schizophrenia