Photochemical HAT-Mediated Site-Selective C(sp³)−H Aminoalkylation of Cubanes Catalyzed by TBADT

Key Points

• This research aims to develop a method for selective C–H aminoalkylation of cubanes using TBADT-mediated HAT.
• Utilized TBADT as a photocatalyst for HAT (hydrogen atom transfer) reactions.
• Achieved C–H aminoalkylation without pre-functionalization of cubanes.
• Conducted reactions under mild conditions to evaluate efficiency.
• Successfully synthesized valuable 3D cubane-aryl methylamine bioisosteres.
• Demonstrated the effectiveness of the radical addition strategy in C–H functionalization.