The Molecular Mechanism of Temperature-dependent p53C Phase Separation Accelerated by Oncogenic Mutations: Insights from All-atom and Coarse-grained Molecular Dynamics Simulations

Key Points

• To investigate how temperature and oncogenic mutations affect the phase separation of mutant p53C.
• Conducted all-atom and coarse-grained molecular dynamics simulations.
• Analyzed the behavior of p53C under varying temperature conditions.
• Examined the impact of specific oncogenic mutations on p53C aggregation.
• Mutant p53C showed increased phase separation at elevated temperatures.
• Temperature-dependent phase separation was significantly accelerated by oncogenic mutations.
• Findings suggest that p53C aggregation may contribute to cancer aggressiveness.