Sevoflurane-induced hemispheric cerebral blood flow reduction in mice with revived global perfusion after carotid artery occlusion

Key Points

• The aim is to investigate the effects of sevoflurane on cerebral blood flow following carotid artery occlusion in a mouse model.
• Utilized the rUCCAO model in mice to assess hemodynamic changes.
• Administered sevoflurane to observe its effects on vasodilation.
• Analyzed cerebrovascular reactivity pre- and post-carotid occlusion.
• Sevoflurane reduced cerebral blood flow selectively due to impaired vasodilation.
• Compromised cerebrovascular reactivity was identified as a key alteration following carotid occlusion.