Case: An 18-year-old man with severe hemophilia A (without inhibitors) developed severe left knee deformity after an untreated injury, resulting in wheelchair dependence. He underwent knee arthrodesis under factor VIII cover but developed a postoperative hematoma and inhibitor formation. Following evacuation and treatment with activated prothrombin complex concentrate and recombinant factor VII, solid fusion and pain relief were achieved within 6 months. Three years later, he walks independently with improved Lower Extremity Functional Scale and SF-36 scores. Conclusion: Knee arthrodesis remains a viable salvage procedure that restores function and quality of life when joint preservation or total knee arthroplasty is unfeasible, especially in resource-limited settings.
Rangasamy et al. (Thu,) studied this question.