Iodonium based cross-linking tool for tyrosine conjugation

Key Points

• The aim is to develop a new method for efficient cross-linking of peptides via tyrosine conjugation.
• Utilized fluoroalkyl-aryl iodonium salt from HFO1234yf gas.
• Employed direct fluoroalkenylation of tyrosine residues.
• Facilitated selective conjugation between phenolic compounds.
• Successfully achieved peptide cross-linking through the new methodology.
• Demonstrated the efficiency of the conjugation process.
• Highlighted the versatility of the iodonium-based tool.