Synthesis of Chiral α-Trifluoromethyl amines via Asymmetric reaction of Trifluoromethylated Imines

Key Points

• The aim is to develop efficient synthetic methods for chiral trifluoromethyl amines due to their value as intermediates.
• Synthesis of chiral α-trifluoromethyl amines using trifluoromethylated imines.
• Utilization of asymmetric reaction techniques to achieve chirality.
• Characterization of products for purity and chiral resolution.
• Successfully synthesized various chiral α-trifluoromethyl amines.
• Demonstrated effectiveness of the method in creating biologically active intermediates.
• Achieved high levels of enantiomeric excess in the products.