Salvage therapies for first relapse of SHH medulloblastoma in early childhood

Key Points

• This work aims to evaluate post-relapse survival and prognostic factors in patients with relapsed SHH medulloblastoma.
• International retrospective study with 147 subjects diagnosed with relapsed SHH medulloblastoma.
• Subjects were treated without initial craniospinal irradiation before relapse.
• Used univariable and multivariable Cox models with propensity score analyses to assess survival results.
• The 3-year post-relapse survival rate was 61.6%.
• Patients with local relapse often received salvage treatments like surgery or focal radiotherapy.
• Craniospinal irradiation was associated with improved survival, while high-dose chemotherapy showed clinical importance without statistical significance.