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Palladium-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides | Synapse

February 5, 2026Organic & Biomolecular Chemistry1 citations

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Palladium-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides

JPJunjie PanYancheng Teachers University ZWZi-Yi WangTianjin Normal University BLBingxiao LiTianjin Normal University

Key Points

The aim is to develop a palladium-catalyzed method for cyclization using alkene-tethered carbamoyl chlorides.
Palladium-catalyzed reactions
Use of alkene-tethered carbamoyl chlorides
Focus on scalability and functional group tolerance
Successfully demonstrated robust scalability of the transformation
Showed good tolerance for various functional groups

Abstract

We describe a palladium-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides. Notable features of this transformation include its robust scalability and good functional group tolerance. The utility of this approach...

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Cite This Study

Pan et al. (Wed,) studied this question.

synapsesocial.com/papers/6984346ff1d9ada3c1fb2964 https://doi.org/https://doi.org/10.1039/d6ob00032k

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