NIR-Responsive Upconversion Nanoplatforms: an Anionic Drug Carrier for ROS Amplification Induced by β-amyloid Fibrils

Key Points

• To investigate the use of NIR-responsive upconversion nanoplatforms and polyoxometalates in amplifying reactive oxygen species to combat beta-amyloid fibrils in Alzheimer’s disease.
• Utilized NIR light to activate upconversion nanoplatforms
• Applied polyoxometalates as anionic therapeutic agents
• Assessed the impact on beta-amyloid fibril depolymerization
• Significant amplification of reactive oxygen species observed
• Depolymerization of beta-amyloid fibrils enhanced with POM therapy
• Potential therapeutic effects on Alzheimer’s disease progression indicated

Abstract