What question did this study set out to answer?

To explore how gut microbiota influences cancer therapy through immune modulation in the tumor microenvironment.

February 8, 2026Cancer Discovery2 citations

Shaping the Tumor Microenvironment: Insights from Host–Microbiota Interactions

KLKhiem C. LamNational Cancer Institute RGRomina S. Goldszmid

Key Points

To explore how gut microbiota influences cancer therapy through immune modulation in the tumor microenvironment.
Discussion of mechanistic interactions between gut microbiota and immune responses.
Analysis of type I interferon's role in these processes.
Gut microbiota significantly affects the efficacy of cancer therapies.
Type I interferon acts as a central mediator in regulating immune responses within tumors.

Abstract

Summary: Gut microbiota has emerged as a determinant of cancer therapy efficacy, shaping immune responses both systemically and locally within the tumor microenvironment. In this piece, we discuss current insights into the mechanistic basis of these interactions, with a focus on type I interferon as a central mediator of microbiota-driven immune modulation.

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Cite This Study

Lam et al. (Fri,) studied this question.

synapsesocial.com/papers/698828010fc35cd7a884724c https://doi.org/https://doi.org/10.1158/2159-8290.cd-25-1350

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