Safety and efficacy of interventions for pain management during venipuncture in neonates: A systematic review and network meta-analysis.

Key Points

• The central aim is to evaluate the safety and efficacy of various interventions for pain management during venipuncture in neonates.
• Systematic review of non-pharmacological and pharmacological interventions
• Network meta-analysis comparing different analgesics
• Assessment of pain reduction effectiveness for neonates
• Breastfeeding was identified as the most effective intervention for pain reduction during venipuncture
• Nonnutritive sucking (NNS) followed breastfeeding as a viable alternative
• Both interventions are feasible in various healthcare settings