Parthenolide attenuated the endometriosis-like lesions by activating autophagy and suppressing NLRP3 inflammasome activity.

Key Points

• The aim is to determine the effects of parthenolide on endometriosis-like lesions through autophagy activation and inflammasome inhibition.
• Used parthenolide treatment on endometriosis-like lesions
• Analyzed AMPK/ULK1 signaling pathway activation
• Assessed NLRP3 inflammasome activity in response to treatment
• Parthenolide significantly activates autophagy processes
• Inhibition of NLRP3 inflammasome activity was observed
• Reduction in the severity of endometriosis-like lesions was noted