What question did this study set out to answer?

The study aims to evaluate the effectiveness of SARS-CoV-2 antigens in detecting total antibodies using an in-house ELISA.

February 9, 2026Open Access

Comparative Evaluation of SARS-CoV-2 Antigens as Capture and Detection Elements in an In-House Antigen-Based ELISA for COVID-19 Total Antibody Detection

Key Points

The study aims to evaluate the effectiveness of SARS-CoV-2 antigens in detecting total antibodies using an in-house ELISA.
Used RBD-based enzyme immunoassay (EIA) for detection
Tested antibody responses in both human and animal samples
Assessed efficiency and reliability for serological surveillance
RBD-based EIA provides reliable detection of total antibodies
The platform is effective for both human and animal testing
Supports applications in vaccine evaluation and One Health monitoring

Abstract

The RBD-based EIA provides a reliable, efficient platform for COVID-19 serological surveillance, suitable for both human and animal testing, and supports broader applications in vaccine evaluation and One Health monitoring.

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Cite This Study

Masangkay et al. (Sun,) studied this question.

synapsesocial.com/papers/698978dff0ec2af6756e71b4 https://doi.org/https://doi.org/10.1016/j.ijid.2026.108461

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