What question did this study set out to answer?

This research aims to assess the diagnostic performance and cost-effectiveness of a novel TST/C-TST combination for latent tuberculosis infection.

February 9, 2026BMC Infectious Diseases0 citationsOpen Access

Evaluation of TST/C-TST combination for latent tuberculosis infection screening: diagnostic performance and cost-effectiveness compared to TST/IGRAs

XZXin ZhangLiaoning University LMLirong MaoThe 309th Hospital of Chinese People's Liberation Army RNRenkun NieChinese People's Liberation Army

Key Points

This research aims to assess the diagnostic performance and cost-effectiveness of a novel TST/C-TST combination for latent tuberculosis infection.
Comparative analysis of TST/C-TST and TST/IGRAs for LTBI screening
Evaluation of diagnostic efficacy using traditional and new methods
Assessment of cost-effectiveness between the two screening approaches
TST/C-TST combination showed higher sensitivity for LTBI detection
Economic analysis indicated significant cost savings with TST/C-TST compared to TST/IGRAs
Promising diagnostic performance may lead to improved LTBI screening practices

Abstract

Within the context of this study, the novel screening strategy that integrates TST and C-TST demonstrates promising efficacy and economic advantages when compared to the traditional TST/IGRAs approach for the detection of LTBI.

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Cite This Study

Zhang et al. (Fri,) studied this question.

synapsesocial.com/papers/698979a6f0ec2af6756e76d3 https://doi.org/https://doi.org/10.1186/s12879-026-12767-z

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