Intensive BP control (<130/80 mmHg) in type 2 diabetes reduced stroke risk by 36% (RR 0.64) and showed a trend to lower major CV events (RR 0.86).
Does intensive blood pressure control reduce stroke and major cardiovascular events in adults with type 2 diabetes?
In adults with type 2 diabetes, intensive blood pressure control significantly reduces the risk of stroke, but does not show conclusive benefits for overall major cardiovascular events, mortality, or heart failure.
Absolute Event Rate: 0% vs 0%
Optimal blood pressure (BP) targets for type 2 diabetes remain controversial. Although intensive BP control reduces cardiovascular risk in the general population, its net benefit in diabetes is uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials comparing intensive BP control (target < 130/80 mmHg or achieved systolic <130 mmHg) with routine control in adults with type 2 diabetes. Databases (PubMed, Embase, Cochrane CENTRAL) were searched through November 2024; two reviewers independently extracted data and assessed bias. Random-effects meta-analysis estimated pooled relative risks (RRs) with 95% confidence intervals (CIs), and trial sequential analysis (TSA) assessed robustness. Eleven trials comprising 24,308 participants met inclusion criteria. Intensive BP control reduced stroke (RR: 0.64; 95% CI: 0.51–0.81) and major cardiovascular events (RR: 0.86; 95% CI: 0.72–1.03) with no significant differences in mortality or heart-failure hospitalization. TSA confirmed firm evidence for stroke reduction, mortality and heart failure results remained inconclusive.
Ikram et al. (Mon,) reported a other. Intensive BP control (<130/80 mmHg) in type 2 diabetes reduced stroke risk by 36% (RR 0.64) and showed a trend to lower major CV events (RR 0.86).