Acinetobacter baumannii promotes gastric cancer metastasis via NA-mediated NAD metabolism reprogramming and glycolytic activation.

Key Points

• The aim is to investigate how Acinetobacter baumannii influences NAD metabolism and promotes metastasis in gastric cancer cells.
• Examined the effects of A. baumannii on NAD metabolism in gastric cancer cells
• Analyzed the role of nicotinic acid synthesis
• Evaluated glycolytic activation in cancer cells
• A. baumannii enhances NAD metabolism in gastric cancer cells
• This enhancement leads to increased metastatic potential
• Establishes a microbiota-metabolism connection relevant for therapeutic strategies