What question did this study set out to answer?

To explore the occurrence of vanishing bile duct syndrome as a rare hepatic paraneoplastic syndrome in Hodgkin’s lymphoma.

February 12, 2026Open Access

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Vanishing Bile Duct Syndrome as an Uncommon Hepatic Paraneoplastic Syndrome in Hodgkin’s Lymphoma

Key Points

To explore the occurrence of vanishing bile duct syndrome as a rare hepatic paraneoplastic syndrome in Hodgkin’s lymphoma.
Case report of a 53-year-old female with jaundice and elevated liver function tests.
Liver biopsy performed to assess liver injury and bile duct status.
Imaging and bone marrow biopsy confirmed Hodgkin’s lymphoma diagnosis.
Patient exhibited cholestasis and mild ductopenia in liver biopsy.
Imaging showed enlarged para-aortic lymph nodes indicative of lymphoma.
Chemotherapy treatment led to normalization of symptoms and liver function tests.

Abstract

Vanishing bile duct syndrome (VBDS) is a rare form of liver injury caused by ischemia, drug reactions, autoimmune diseases, infections, or malignancy. VBDS involves the progressive disappearance of intrahepatic bile ducts, causing cholestasis and biliary cirrhosis, with high mortality if untreated. VBDS can also present as a paraneoplastic syndrome in Hodgkin’s lymphoma (HL). A 53‐year‐old female presented with jaundice, pruritus, diarrhea, and elevated liver function tests (LFTs). A liver biopsy demonstrated cholestasis with mild ductopenia, and imaging revealed enlarged para‐aortic lymph nodes. A bone marrow biopsy confirmed HL, and chemotherapy normalized symptoms and LFTs.

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Cite This Study

Salman et al. (Thu,) studied this question.

synapsesocial.com/papers/698d6e925be6419ac0d546a4 https://doi.org/https://doi.org/10.1155/crhe/4166844

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