Biphasic dissolving microneedles with cyclodextrin inclusion complexes for enhanced delivery of poorly soluble drugs

Key Points

• The study aims to enhance the delivery of poorly soluble drugs using a biphasic dissolving microneedle platform.
• Developed biphasic dissolving microneedles integrated with HP-β-cyclodextrin inclusion complexes.
• Evaluated drug loading efficiency and transdermal delivery capabilities.
• Assessed improvements in bioavailability through testing.
• High drug loading achieved with cyclodextrin inclusion complexes.
• Efficient transdermal delivery demonstrated for poorly soluble drugs.
• Significant improvement in bioavailability noted compared to traditional delivery methods.