Weight-adjusted waist index (WWI) was independently associated with osteoporosis with OR 3.29 (95% CI 2.62–4.14, P<0.001), demonstrating the strongest predictive value among indices (AUC=0.726) in middle-aged and older Chinese adults.
Cross-Sectional (n=10,142)
No
Indices associated with central adiposity and metabolic dysfunction, particularly the weight-adjusted waist index (WWI), provide precise prediction of osteoporosis risk in middle-aged and older Chinese adults.
Effect estimate: Odds Ratios for predictors of osteoporosis and osteopenia adjusted in multivariable logistic regression
To evaluate the associations and comparative performance of novel anthropometric and metabolic indices with osteopenia and osteoporosis among middle-aged and older Chinese adults. A cross-sectional study was conducted among 10,142 Chinese adults aged ≥ 45 years who underwent quantitative computed tomography (QCT) for lumbar spine BMD assessment. Participants were categorized as normal, osteopenia, and osteoporosis. Associations and predictive capabilities of anthropometric indices were analyzed using multivariable logistic regression and receiver operating characteristic (ROC) curve analyses. The prevalences of osteopenia and osteoporosis were 35.14% and 14.05%, respectively. After adjusting for confounders, weight-adjusted waist index (WWI), relative fat mass (RFM), a body shape index (ABSI), triglyceride-glucose (TyG) index, and glycated hemoglobin (HbA1c) were found to be independently associated with osteopenia and osteoporosis. Among all indices, WWI demonstrated the strongest predictive value for osteoporosis (area under the curve = 0.726), followed by RFM and ABSI. In contrast, BMI and the visceral adiposity index (VAI) showed no significant associations with low BMD. Indices associated with central adiposity and metabolic dysfunction, especially WWI, may provide more precise prediction of osteoporosis risk. Incorporating such indices into early risk stratification for osteoporosis among older Chinese adults may have potential clinical utility.
Wang et al. (Wed,) conducted a cross-sectional in Middle-aged and older Chinese adults (≥45 years) undergoing QCT for lumbar spine BMD assessment to evaluate osteopenia and osteoporosis (n=10,142). Weight-adjusted waist index (WWI) was independently associated with osteoporosis with OR 3.29 (95% CI 2.62–4.14, P<0.001), demonstrating the strongest predictive value among indices (AUC=0.726) in middle-aged and older Chinese adults.