Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells

Key Points

• The research investigates the transcriptional differences in sepsis, focusing on the regulation of the SNHG5/miR-324-5p/CDK16 axis in T cells.
• Utilized single-cell RNA sequencing to analyze transcriptional profiles in sepsis
• Examined T cell responses related to sepsis-related lymphopenia
• Assessed modulation of SNHG5, miR-324-5p, and CDK16
• Identified significant transcriptional heterogeneity among T cells in sepsis
• Found down-regulation of the SNHG5/miR-324-5p/CDK16 axis in T cells
• Suggested that SNHG5 may serve as a potential therapeutic target for sepsis management