Abstract Background Orthokeratology (OK) has been widely adopted as a non-surgical intervention to slow myopia progression in children and adolescents. In China, where myopia prevalence is exceptionally high, OK lenses are commonly prescribed to school-aged children as an early intervention strategy. As these individuals reach adulthood, many pursue permanent refractive correction—such as small-incision lenticule extraction (SMILE)—to meet unaided visual acuity standards required for university entrance, military service, or certain occupations. However, the long-term morphological effects of OK wear and their potential impact on SMILE outcomes remain inadequately understood. This study aimed to evaluate ocular biometric and corneal morphological changes following long-term OK lens discontinuation and to compare the visual and surgical outcomes of SMILE between former OK users and spectacle-wearing controls. Methods This retrospective comparative study included 44 myopic eyes—22 from patients with a history of OK lens wear (average duration: 64.8 ± 22.6 months; discontinuation ≥ 3 months) and 22 from age- and refractive error–matched controls. Examinations were conducted pre-OK (baseline), pre-SMILE, and at 1 month, 6 months, and final follow-up. Parameters included uncorrected and corrected distance visual acuity (UDVA, CDVA), corneal topography, pachymetry, volume, curvature, and higher-order aberrations. Astigmatic outcomes were evaluated using Alpins vector analysis. Results After OK discontinuation, the OK group exhibited increased corneal astigmatism ( P = 0.030), spherical aberration ( P = 0.036), and total aberrations ( P = 0.034), as well as decreased vertical coma ( P = 0.004), central corneal thickness ( P 0.050). Vector analysis revealed no significant group differences in astigmatic correction. Conclusions SMILE remains a viable option for former OK users; the observed reduction in CCT after lens discontinuation has minimal impact on refractive surgery selection.
Zhou et al. (Fri,) studied this question.