What question did this study set out to answer?

This research aims to understand how the timing of surgical intervention impacts the outcomes in patients with small intestinal neuroendocrine tumours (siNET).

February 21, 2026Open Access

Oncological Outcomes after Elective and Emergency Resection of Small Intestinal Neuroendocrine Tumours

Key Points

This research aims to understand how the timing of surgical intervention impacts the outcomes in patients with small intestinal neuroendocrine tumours (siNET).
Conducted a retrospective observational cohort study
Analyzed patients diagnosed with siNET receiving surgical intervention from 2008 to 2025
Included 44 patients, differentiating between those who underwent elective and emergency resections
30% of surgeries were emergency resections, 70% elective
Emergency presentations were predominantly due to small bowel obstruction
Emergency surgeries showed a higher rate of post-operative macroscopic residual disease
No significant differences in overall survival or recurrence-free survival between groups

Abstract

Abstract Purpose Small intestinal neuroendocrine tumour (siNET) has distinct features and disease course compared to other gastrointestinal neuroendocrine tumours. While they mostly present with subtle symptoms, they also can present acutely requiring emergency surgical intervention. We assessed the impact of surgical intervention timing on oncological outcomes of siNET. Method A retrospective observational single centre cohort study of all patients diagnosed with siNET, and received surgical intervention at a tertiary level hospital between 2008 and 2025. Results A total of 66 patients were diagnosed with SiNET. 22 patients were excluded due to incomplete data (9 patients) and not meeting the eligibility criteria (13 patients). Total of 44 patients met the inclusion criteria, with 30% underwent emergency resection ( n = 13) and 70% underwent elective resection ( n = 31). Small bowel obstruction represented the most common cause for emergency presentations (61%), while incidental radiological findings (39%) and carcinoid syndrome (35%) accounted for most elective presentations. Emergency cases were associated with the absence of pre-operative somatostatin receptor imaging, less findings of mesenteric mass (31% vs. 81%), more likelihood of post operative macroscopic residual disease (46% vs. 23%) and disease specific mortality (75% vs. 23%). However, there was no statistically significant difference between the two groups in primary and secondary oncological outcomes. There were no operative or in-hospital mortality in either group as well as no significant difference in complications rates between the groups. Conclusions Although emergency surgery was associated with limited preoperative staging and higher proportion of R2 resections, no statistically significant differences in overall survival, recurrence-free survival, carcinoid symptom resolution or local complications were observed. However, these results need to be interpreted cautiously due to the small sample size of the study.

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