What question did this study set out to answer?

This research aims to determine the relationship between hormone therapy and the development of Fuchs endothelial corneal dystrophy.

February 21, 2026JAMA Ophthalmology0 citations

Fuchs Endothelial Corneal Dystrophy

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AMAmy E. MillenUniversity at Buffalo, State University of New York JNJing NieUniversity at Buffalo, State University of New York JWJean Wactawski-WendeUniversity at Buffalo, State University of New York

Key Points

This research aims to determine the relationship between hormone therapy and the development of Fuchs endothelial corneal dystrophy.
Conducted a post hoc secondary analysis of the Women’s Health Initiative study.
Assessed randomized hormone therapy use among participants.
Evaluated subsequent incidents of Fuchs endothelial corneal dystrophy.
Findings indicate an association between hormone therapy use and the incidence of Fuchs endothelial corneal dystrophy.
The analysis highlights trends in corneal disease development in women undergoing hormone treatment.

Abstract

This post hoc secondary analysis of the Women’s Health Initiative study assesses whether randomization to hormone therapy use was associated with subsequent incident Fuchs endothelial corneal dystrophy.

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Fuchs Endothelial Corneal Dystrophy

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Abstract

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