A young man presented with mediastinal mass, pleural and pericardial effusions: a rare case of CD123-positive myeloid sarcoma | Synapse
February 22, 2026
A young man presented with mediastinal mass, pleural and pericardial effusions: a rare case of CD123-positive myeloid sarcoma
Key Points
The aim is to highlight a rare presentation of myeloid sarcoma and its implications in diagnosis and treatment.
Case presentation of a young man with identified symptoms.
Imaging and laboratory analysis conducted to confirm diagnosis.
Focus on the pathological features of CD123-positive myeloid sarcoma.
Confirmed diagnosis of myeloid sarcoma with associated pleural and pericardial effusions.
Discussion on the rarity of the case and its relevance to acute myeloid leukaemia.
Abstract
Background: Myeloid sarcoma is an extramedullary tumour composed of myeloid blasts, with or without maturation. Myeloid sarcoma is reported in 2–9% of patients with acute myeloid leukaemia (AML). 1