A 64-year-old male presented with several weeks of ataxia, headache and dizziness and was found to have multiple right cerebellar lesions. The remainder of staging imaging performed was unremarkable. He underwent gross total resection of the cerebellar lesions. Histopathology exhibited papillary and micropapillary architecture. Further immunohistochemistry showed CK7positive, CD20 negative and CDX2 positive staining. TTF1 negative excluded lung and thyroid carcinoma, meanwhile NKX3.1 negative excluded metastatic lesion originating from prostate. The results are consistent with metastatic adenocarcinoma, likely of upper gastrointestinal tract origin. He was subsequently referred for oncologic treatment.
Lim et al. (Sun,) studied this question.