Abstract: The coexistence of atopic dermatitis and eosinophilic gastroenteritis represents an uncommon clinical phenotype that is often underrecognized, resulting in delayed diagnosis and suboptimal treatment. This report aims to delineate the clinical characteristics of such cases and highlight recent developments in diagnostic and therapeutic approaches, thereby supporting improved clinical decision-making. A 50-year-old man presented with widespread atopic dermatitis-like cutaneous lesions and recurrent gastrointestinal symptoms consistent with eosinophilic gastroenteritis. Symptom exacerbation exhibited seasonal variation, particularly during spring and autumn. Laboratory investigations revealed elevated eosinophil percentages and absolute counts, as well as increased total serum IgE and positive specific IgE to allergens. Histopathological examination of gastroscopy and colonoscopy biopsy specimens demonstrated marked eosinophilic infiltration of the gastrointestinal mucosa, confirming the diagnosis of eosinophilic gastroenteritis accompanied by atopic dermatitis. Although oral antihistamines provided temporary symptomatic relief, clinical symptoms recurred after medication withdrawal. Atopic dermatitis and eosinophilic gastroenteritis appear to share a common allergen-driven pathogenesis. Accurate identification of causative allergens, in conjunction with the assessment of serum IgE levels and eosinophil counts, is critical for effective diagnosis and management. Therapeutic interventions targeting allergic inflammation have demonstrated efficacy in addressing both conditions. Keywords: gastroenteritis, eosinophils, atopic dermatitis, corticosteroid, abdominal distension
Song et al. (Sun,) studied this question.