What question did this study set out to answer?

To explore the complications of portal biliopathy in patients suffering from non-cirrhotic portal hypertension and identify treatment options.

February 22, 2026

Non-cirrhotic portal hypertension complicated by portal biliopathy

Key Points

To explore the complications of portal biliopathy in patients suffering from non-cirrhotic portal hypertension and identify treatment options.
Review of patient cases with portal biliopathy associated with non-cirrhotic portal hypertension.
Assessment of the incidence of asymptomatic and symptomatic forms of portal biliopathy.
Analysis of complications arising from biliary tract interventions.
Asymptomatic portal biliopathy occurs in 81% to 100% of NCPH patients, significantly higher than the 0-33% incidence in cases with hepatic block.
Symptomatic portal biliopathy is found in only 5% to 33% of patients with NCPH.
Interventions on the biliary tract may lead to severe blood loss due to coagulopathy.

Abstract

The earliest references to association between mechanical jaundice and non-cirrhotic portal hypertension (NCPH) are by Fraser et al. (1944) and Gibson et al. (1965). The term “portal hypertension biliopathy” was proposed by Dhiman et al. (1999). The incidence of asymptomatic form of portal hypertension biliopathy (PHB) in patients with NCPH ranges from 81% to 100% that is significantly higher compared to patients with hepatic block (0—33%). Symptomatic form of PHB occurs only in 5—33% of patients. Any intervention on biliary tract in patients with PHB may result in significant blood loss due to coagulopathy. Currently, there is no consensus on optimal treatment algorithm for patients with symptomatic PHB. The authors present several patients with PHB complicated by mechanical jaundice and variants for correction of this complication.

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