Nano-assembly and cytotoxicity of the L-valine-polyamine conjugates of betulinic acid

Key Points

• The research aims to synthesize and evaluate the cytotoxicity of L-valine-polyamine conjugates of betulinic acid.
• Synthesized six target derivatives of betulinic acid.
• Developed a series of 15 new compounds.
• Characterized structures of target compounds and intermediates.
• Identified several compounds with potential cytotoxic effects.
• Noted variances in effectiveness across the synthesized derivatives.