What question did this study set out to answer?

To explore the structural and mechanistic diversity of vitamin B12-dependent radical SAM enzymes and their evolutionary relationships.

February 26, 2026Open Access

Novel chemistry and structural perspectives in vitamin B 12 -dependent radical SAM enzymes

Key Points

To explore the structural and mechanistic diversity of vitamin B12-dependent radical SAM enzymes and their evolutionary relationships.
Review of literature on vitamin B12-dependent radical SAM enzymes
Analysis of structural data and catalytic mechanisms
Comparative studies with other B12-dependent enzymes
Highlighted diverse structures and mechanisms of radical SAM enzymes
Identified evolutionary connections to other B12-dependent enzymes
Showed implications for understanding enzyme function and catalysis.

Abstract

This review highlights the structural and mechanistic diversity of B 12 -dependent radical SAM enzymes and their evolutionary links to other B 12 -dependent enzymes.

Novel chemistry and structural perspectives in vitamin B 12 -dependent radical SAM enzymes

Key Points

Abstract

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